Sep 23, 2023  
2023-2024 General Catalog 
2023-2024 General Catalog
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MLT 171 - Immunology & Serology

Last Date of Approval: Fall 2019

3 Credits
Total Lecture Hours: 45
Total Lab Hours: 0
Total Clinical Hours: 0
Total Work-Based Experience Hours: 0

Course Description:
This course will discuss the basic concepts of the immune system, and its application to diagnostic testing. Human diseases and the laboratory immunology testing for those diseases will be discussed. The principles and procedures of routine techniques for serological testing are presented. This course will help students gain scientific literacy vital to making important life decisions. This course will help students develop the critical thinking skills needed to function as an entry-level medical laboratory technician and satisfies curriculum requirements of the National Accrediting Agency for Clinical Laboratory Sciences.

Corequisites: BIO-173
Prerequisites: BIO-168, MLT-111  
Mode(s) of Instruction: traditional/face-to-face

Credit for Prior Learning: There are no Credit for Prior Learning opportunities for this course.

Course Fees: Course Materials: $35.00

Common Course Assessment(s): None

Student Learning Outcomes and Objectives:
  • Describe the different structures in immune system and their functions.
    • Match developments in serology and immunology with the scientists credited with their discovery.
    • Differentiate between cellular and humoral immunity.
    • Match developments in serology and immunology with the scientists credited with their discovery.
    • Differentiate between cellular and humoral immunity.
    • List the functions of components of the natural external defense system.
    • Summarize the interaction of the external and internal defense system of natural immunity needed to keep an individual in good health.
    • Explain what makes a substance a good immunogen.
    • State the anatomic location of antigens of the major histocompatibility complex and cellular interactions.
    • Define terms related to the genetics of immunologic characteristics.
    • Identify anatomic structures classified as primary and secondary lymphoid organs and tissues.
    • State surface markers associated with specific lymphocyte types.
    • Summarize the interaction between cellular and humoral components of the acquired immune system
    • Describe basic immunoglobulin structure and cleavage with enzymes.
    • Describe specific function and structure of the 5 classes of immunoglobulins.
    • Compare and contrast antibody production during primary and secondary immune responses.
    • Describe the nature of the components of the classic complement pathway and formation of the 3 principle units.
    • Describe the nature of the components of the alternative pathway.
    • Describe the nature of the components of the lectin pathway.
    • Recognize the biologic manifestations associated with complement deficiencies or the activation of complement pathways.
  • Discuss the pathophysiology of various immune disorders.
    • Define hypersensitivity and the immune mediator responsible for each of the four types.
    • Describe the triggering mechanism of Type I reactions.
    • Describe how cellular damage occurs in types of cytotoxic reactions.
    • Identify examples of Type III hypersensitivities, including the nature of the antigen and mechanism of cellular injury.
    • Describe how Type IV sensitivity differs from the other three types.
    • Explain the immune mechanism involved in specific Type IV reactions.
    • Describe the clinical signs and immunologic manifestations of systemic lupus erythematosus.
    • Describe the characteristics of the key antibody found in rheumatoid arthritis.
    • Describe the clinical manifestations of the transmission and stages of syphilis.
    • Describe clinical manifestations of Lyme disease and its transmission.
    • List the five types of hepatitis according to causative virus.
    • List members of the human herpes family and symptoms and disorders associated with each.
    • Describe the significance of Cytomegalovirus in specific populations and detection methods.
    • Differentiate between primary and secondary infections caused by the Varicella Zoster Virus.
    • Discuss the methods of acquiring rubella infections, signs and symptoms, and antibody detection.
    • Discuss cause, symptoms, and appropriate testing for other viral infections.
    • Describe the structure of the HIV virus.
    • Describe conditions that are conducive to HIV transmission and replication.
  • Explain the theories and test principles of serological testing methods, and relate results to specific immune disorders.
    • Identify the principles used in lab methods to classify lymphocytes.
    • Relate immunoglobulins to their location on a serum protein electrophoresis pattern.
    • Summarize the procedure used to produce monoclonal antibodies.
    • Define affinity and avidity and their influence on antigen-antibody reactions.
    • Describe laboratory reactions based on precipitation between antigen and antibody.
    • Describe the stages of agglutination reactions between soluble antibody and insoluble antigen.
    • Explain and give applications for the direct antiglobulin test.
    • Explain and give applications for the indirect Coombs test.
    • Discuss serologic testing for Lyme disease including false positive and false negative results.
    • Describe testing that is available for immediate hypersensitivities and its use.
    • Describe the lab findings in rheumatoid arthritis.
    • Distinguish between test methodology and reactions using direct, trepomenal and nontreponemal tests for syphilis.
    • Match specific antigens and antibodies with detection stages in types of viral hepatitis.
    • List Epstein-Barr virus specific markers according to the stage in the disease in which they are detected.
    • Describe clinical symptoms and lab findings associated with the three clinical categories of HIV infections.
    • Summarize laboratory methods for detection of the HIV virus.

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