Mar 28, 2024  
2023-2024 General Catalog 
    
2023-2024 General Catalog
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MLT 243 - Clinical Chemistry II


Last Date of Approval: Spring 2022

2 Credits
Total Lecture Hours: 30
Total Lab Hours: 0
Total Clinical Hours: 0
Total Work-Based Experience Hours: 0

Course Description:
This is a study of the endocrine system, tumor markers, therapeutic drugs, toxicology and vitamins, and correlating test results with states of health and disease. This course will help students gain scientific literacy vital to making important life decisions. The course is designed to help students develop the hands-on and critical thinking skills needed to function as an entry-level medical laboratory technician and satisfies curriculum requirements of the National Accrediting Agency for Clinical Laboratory Sciences.

Prerequisites: CHM 110  and CHM 111 , or CHM 112  , MLT 241  
Mode(s) of Instruction: traditional/face-to-face

Credit for Prior Learning: There are no Credit for Prior Learning opportunities for this course.

Course Fees: None

Common Course Assessment(s): None

Student Learning Outcomes and Objectives:
  1. Explain the location and determine the function of endocrine glands and the laboratory tests used to identify endocrine system disorders.
  2. Define pharmacokinetics and the laboratory’s role in therapeutic drug monitoring and toxicology testing in the evaluation of various drug therapies and potentially harmful substances.
  3. Explain the role and characteristics of tumor markers and how they are used to diagnose and monitor treatment of neoplasms.
  4. Differentiate and identify the properties of common laboratory instrumentation and testing methodologies used in the chemical analysis of laboratory specimens.
  5. Define the role, function, and characteristics of vitamins, minerals, and trace elements and the disease states associated with abnormalities of each.
  6. Explain the different types and functions of body fluids and the laboratory analysis and abnormalities associated with them.

Course Objectives

  1. Define hormones and discuss their various functions.
  2. Discuss the different structural classes of hormones.
  3. Define the mechanism of control when dealing with hormones.
  4. Differentiate primary, secondary, and tertiary disorders that are associated with hormones.
  5. Differentiate components associated with the hormones and the laboratory findings.
  6. Name the parts of the thyroid gland.
  7. Describe the action and regulation of thyroid hormones.
  8. Distinguish the various assays used to determine abnormal thyroid function.
  9. Name the laboratory findings, signs, and symptoms associated with the major thyroid disorders.
  10. Define the mechanism used by the body to process a drug.
  11. Define the Pharmacokinetics of therapeutic drugs and describe the concepts used to manage them.
  12. Define key terms in therapeutic drug monitoring.
  13. Explain proper sample collection of therapeutic drugs.
  14. List specific classifications of drugs which are commonly prescribed and monitored giving examples of each.
  15. Define tumor markers and identify where they are located.
  16. Discuss the different tumor marker tests and give the characteristics of “ideal tumor markers.”
  17. Name the tumor specific antigens and discuss the significance of them.
  18. Discuss the placental proteins and identify how they are useful.
  19. Discuss the different enzymes that are valued as tumor markers.
  20. Describe the hormones that are used as tumor markers.
  21. Discuss why steroid receptors are important and how they are used.
  22. Define toxicology.
  23. Discuss the pathologic mechanisms of the different toxicants.
  24. Discuss the different areas of toxicants such as specific agents and therapeutic drugs and list the ranges and effects of these toxicants.
  25. Discuss the spectrophotometer in terms of its parts and relate it to Beer’s Law.
  26. Identify an atomic absorption spectrophotometer and explain the principles and advantages to it.
  27. Discuss the principles of fluorometry and describe its advantages.
  28. Discuss Nephelometry and Turbidimetry and the disadvantages of each.
  29. Define and discuss refractometry.
  30. Compare the operation and components of the pH, pCO2, pO2 and ion selective electrodes.
  31. Discuss the measurement of blood gases.
  32. Define osmometry and the colligative properties associated with it.
  33. Discuss electrophoresis in association with movement, pH, endosmosis, time and wick effect.
  34. Compare and contrast the three basic approaches to instrument automation.
  35. Discuss operation and function of centrifuges.
  36. Define vitamins and discuss the water soluble and fat soluble characteristics.
  37. Identify the water soluble vitamins along with the functions and deficiencies.
  38. List the fat soluble vitamins and their functions, sources, and deficiencies.
  39. Explain and discuss the digestion, transport, and regulation of iron in the body.
  40. Define minerals and differentiate trace minerals from major minerals.
  41. Define amniotic fluid and describe its role in pregnancy.
  42. Describe the physiologic basis for tests of fetal maturity.
  43. Describe the origin and physiologic role of alpha-fetoprotein in the fetus and explain how its measurement in maternal serum is of value in assessing the risk of neural tube defect.
  44. Explain why confirmatory tests of alpha-fetoprotein are essential.
  45. Define the different body fluids including CSF, peritoneal, and thoracic, and describe their role in the body.



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