MLT 171 - Immunology & Serology

BIO 168 - Human Anatomy and Physiology I  
Mode(s) of Instruction: traditional/face-to-face

Credit for Prior Learning: There are no Credit for Prior Learning opportunities for this course.

Course Fees: Course Materials: $35.00

Common Course Assessment(s): None

Student Learning Outcomes and Objectives:
Unit 1: Nature of the Immune System

1. Match developments in serology and immunology with the scientists credited with their discovery.
2. Differentiate between cellular and humoral immunity.
3. Match developments in serology and immunology with the scientists credited with their discovery.
4. Differentiate between cellular and humoral immunity.
5. List the functions of components of the natural external defense system.
6. Summarize the interaction of the external and internal defense system of natural immunity needed to keep an individual in good health.
7. Explain what makes a substance a good immunogen.
8. State the anatomic location of antigens of the major histocompatibility complex and cellular interactions.
9. Define terms related to the genetics of immunologic characteristics.
10. Identify anatomic structures classified as primary and secondary lymphoid organs and tissues.
11. State surface markers associated with specific lymphocyte types.
12. Summarize the interaction between cellular and humoral components of the acquired immune system.
13. Identify the principles used in lab methods to classify lymphocytes.

Unit 2: Antibodies & Complement

1. Describe basic immunoglobulin structure and cleavage with enzymes.
2. Describe specific function and structure of the 5 classes of immunoglobulins.
3. Relate immunoglobulins to their location on a serum protein electrophoresis pattern.
4. Compare and contrast antibody production during primary and secondary immune responses.
5. Summarize the procedure used to produce monoclonal antibodies.
6. Describe the nature of the components of the classic complement pathway and formation of the 3 principle units.
7. Describe the nature of the components of the alternative pathway.
8. Describe the nature of the components of the lectin pathway.
9. Recognize the biologic manifestations associated with complement deficiencies or the activation of complement pathways.

Unit 3: Basic Immunologic Procedures

1. Define affinity and avidity and their influence on antigen-antibody reactions.
2. Describe laboratory reactions based on precipitation between antigen and antibody.
3. Describe the stages of agglutination reactions between soluble antibody and insoluble antigen.
4. Explain and give applications for the direct antiglobulin test.
5. Explain and give applications for the indirect Coombs test.
6. Define hypersensitivity and the immune mediator responsible for each of the four types.
7. Describe the triggering mechanism of Type I reactions.
8. Describe testing that is available for immediate hypersensitivities and its use.
9. Describe how cellular damage occurs in types of cytotoxic reactions.
10. Identify examples of Type III hypersensitivities, including the nature of the antigen and mechanism of cellular injury.
11. Describe how Type IV sensitivity differs from the other three types.
12. Explain the immune mechanism involved in specific Type IV reactions.

Unit 4: Immune Disorders

1. Describe the clinical signs and immunologic manifestations of systemic lupus erythematosus.
2. Describe the characteristics of the key antibody found in rheumatoid arthritis.
3. Describe the lab findings in systemic autoimmune diseases.
4. List the signs and clinical manifestations of organ-specific autoimmune diseases.
5. Describe the lab findings in organ-specific autoimmune diseases.
6. Match autoantibodies that are produced to the organ specific disease they are associated with.
7. Identify patterns associated with antinuclear antibody testing.
8. Describe the principle of enzyme immunoassay tests.
9. Describe the clinical manifestations of the transmission and stages of syphilis.
10. Distinguish between test methodology and reactions using direct, trepomenal and nontreponemal tests for syphilis.
11. Describe clinical manifestations of Lyme disease and its transmission.
12. Discuss serologic testing for Lyme disease including false positive and false negative results.

Unit 5: Serology of Infectious Diseases

1. List the five types of hepatitis according to causative virus.
2. Match specific antigens and antibodies with detection stages in types of viral hepatitis.
3. List members of the human herpes family and symptoms and disorders associated with each.
4. List Epstein-Barr virus specific markers according to the stage in the disease in which they are detected.
5. Describe the significance of Cytomegalovirus in specific populations and detection methods.
6. Differentiate between primary and secondary infections caused by the Varicella Zoster Virus.
7. Discuss the methods of acquiring rubella infections, signs and symptoms, and antibody detection.
8. Discuss cause, symptoms, and appropriate testing for other viral infections.
9. Describe the structure of the HIV virus.
10. Describe conditions that are conducive to HIV transmission and replication.
11. Describe clinical symptoms and lab findings associated with the three clinical categories of HIV infections.
12. Summarize laboratory methods for detection of the HIV virus.