MLT 171 - Immunology & Serology

• Describe the different structures in immune system and their functions.
  • Match developments in serology and immunology with the scientists credited with their discovery.
  • Differentiate between cellular and humoral immunity.
  • Match developments in serology and immunology with the scientists credited with their discovery.
  • Differentiate between cellular and humoral immunity.
  • List the functions of components of the natural external defense system.
  • Summarize the interaction of the external and internal defense system of natural immunity needed to keep an individual in good health.
  • Explain what makes a substance a good immunogen.
  • State the anatomic location of antigens of the major histocompatibility complex and cellular interactions.
  • Define terms related to the genetics of immunologic characteristics.
  • Identify anatomic structures classified as primary and secondary lymphoid organs and tissues.
  • State surface markers associated with specific lymphocyte types.
  • Summarize the interaction between cellular and humoral components of the acquired immune system
  • Describe basic immunoglobulin structure and cleavage with enzymes.
  • Describe specific function and structure of the 5 classes of immunoglobulins.
  • Compare and contrast antibody production during primary and secondary immune responses.
  • Describe the nature of the components of the classic complement pathway and formation of the 3 principle units.
  • Describe the nature of the components of the alternative pathway.
  • Describe the nature of the components of the lectin pathway.
  • Recognize the biologic manifestations associated with complement deficiencies or the activation of complement pathways.
• Discuss the pathophysiology of various immune disorders.
• • Define hypersensitivity and the immune mediator responsible for each of the four types.
  • Describe the triggering mechanism of Type I reactions.
  • Describe how cellular damage occurs in types of cytotoxic reactions.
  • Identify examples of Type III hypersensitivities, including the nature of the antigen and mechanism of cellular injury.
  • Describe how Type IV sensitivity differs from the other three types.
  • Explain the immune mechanism involved in specific Type IV reactions.
  • Describe the clinical signs and immunologic manifestations of systemic lupus erythematosus.
  • Describe the characteristics of the key antibody found in rheumatoid arthritis.
  • Describe the clinical manifestations of the transmission and stages of syphilis.
  • Describe clinical manifestations of Lyme disease and its transmission.
  • List the five types of hepatitis according to causative virus.
  • List members of the human herpes family and symptoms and disorders associated with each.
  • Describe the significance of Cytomegalovirus in specific populations and detection methods.
  • Differentiate between primary and secondary infections caused by the Varicella Zoster Virus.
  • Discuss the methods of acquiring rubella infections, signs and symptoms, and antibody detection.
  • Discuss cause, symptoms, and appropriate testing for other viral infections.
  • Describe the structure of the HIV virus.
  • Describe conditions that are conducive to HIV transmission and replication.
• Explain the theories and test principles of serological testing methods, and relate results to specific immune disorders.
• • Identify the principles used in lab methods to classify lymphocytes.
  • Relate immunoglobulins to their location on a serum protein electrophoresis pattern.
  • Summarize the procedure used to produce monoclonal antibodies.
  • Define affinity and avidity and their influence on antigen-antibody reactions.
  • Describe laboratory reactions based on precipitation between antigen and antibody.
  • Describe the stages of agglutination reactions between soluble antibody and insoluble antigen.
  • Explain and give applications for the direct antiglobulin test.
  • Explain and give applications for the indirect Coombs test.
  • Discuss serologic testing for Lyme disease including false positive and false negative results.
  • Describe testing that is available for immediate hypersensitivities and its use.
  • Describe the lab findings in rheumatoid arthritis.
  • Distinguish between test methodology and reactions using direct, trepomenal and nontreponemal tests for syphilis.
  • Match specific antigens and antibodies with detection stages in types of viral hepatitis.
  • List Epstein-Barr virus specific markers according to the stage in the disease in which they are detected.
  • Describe clinical symptoms and lab findings associated with the three clinical categories of HIV infections.
  • Summarize laboratory methods for detection of the HIV virus.